Here's an interesting way to do photobleaching with cleared tissue: Add 0.1% H2O2 to the clearing medium and blast with LEDs for 24h at RT. Also includes very detailed instructions for building an LED photobleaching setup - the samples ate placed between two PCBs with LEDs in a ventilated box.

Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues
Murakami et al., preprint at biorxiv 2025
https://www.biorxiv.org/content/10.1101/2025.02.24.639965v2.full.pdf

#EEG #Neuroscience #RealTime

I'm curious — if you use EEG and have an online mapping (colours or symbols on head surface) — what would be the most useful to you?

Researchers at UCLA Health have developed the Network Correspondence Toolbox, an open-source digital tool that allows scientists to compare brain imaging data across 16 widely used brain maps. This innovation aims to standardize brain region identification, enhancing collaboration and accelerating research into neurological conditions like Alzheimer's and Parkinson's.

@goodnews

#GoodNews #Neuroscience #BrainResearch #OpenSource #UCLAHealth
https://thedebrief.org/neuroscientists-unveil-digital-translator-to-map-the-mind-like-never-before/

The new company Nudge https://nudge.com is with the help of quite a few ex-Neuralink employees developing a phased array ultrasound helmet for transcranial focused ultrasound stimulation (tUS/tFUS) of the human brain. #BCI #NeuroTech #neuroscience

Theoretically, the phased array ultrasound helmet being developed by Nudge could lead to a non-invasive visual prosthesis through transcranial focused ultrasound stimulation (tUS/tFUS) of primary visual cortex V1 at ~1 mm focus spots.

Me - Flux of mind
Ai- influx of artificial mind
/random
Okay seriously
Does mind have a shape ( i mean head clearly does ) and does the answer to it changes how the subject thinks?
#psychology #neuroscience

A simple animal’s response to sickness highlights the nervous system’s surprising degrees of flexibility
https://picower.mit.edu/news/simple-animals-response-sickness-highlights-nervous-systems-surprising-degrees-flexibility
#neuroscience

It's all about balance: According to a study by #CharitéBerlin & @bih_charite, the #brain can only function optimally if the neurons work together in a way that is neither too orderly nor too disorderly. Read more in our Paper spotlight:

https://www.charite.de/en/research/paper_spotlight/new_findings_on_the_functioning_of_brain_networks

What, I ask you, is the point of thinking hard about neuroscience and the brain, in the US right now?

I mean, we keep going because as scientists that's what we do. Pounding away on models and data, testing and refining, figuring what works and what doesn't--it's what we do. Even if the $$ runs out, the hypotheses (as long as they are communicated to the wider community who might have the resources to test it and build on it) are still a good thing to do.

My $.02.

Increased global and regional connectivity in propofol-induced unconsciousness: human intracranial electroencephalography study
https://pubmed.ncbi.nlm.nih.gov/40179374/
#neuroscience

The Institute of Neuroscience Paris-Saclay (NeuroPSI) is seeking new group leaders for the coming years:
https://neuropsi.cnrs.fr/ao2025/

Deadline: May 30th, 2025.

"#NeuroPSI currently hosts 25 teams that use a variety of animal models and combine experimental and theoretical approaches to understand how different types of neural architectures generate distinct behaviors."

"We particularly encourage young and mid-career #Drosophila researchers to apply to keep the momentum for Drosophila neurobiology in the Paris-Saclay area. With currently 5 teams working with this model, the institute has the necessary infrastructure for fly rearing and experimentation which makes it great place for Drosophilists to join."

Via Tihana Jovanic @tihana

Maggots. We really don't give then enough credit. They can do so much with so little:

"Sensation of electric fields in the Drosophila melanogaster larva", Tadres et al. 2025 (Matthieu Louis' lab).
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00299-4

(2024) Dynamic modulation of mouse thalamocortical visual activity by salient sounds https://www.cell.com/iscience/fulltext/S2589-0042(24)00585-6 "sound-driven modulations of visual activity are not exclusive to V1", "thalamocortical inputs from the dLGN to V1 contribute to shaping V1 visual response to sound"; #neuroscience

Let's beat Elon Musk's Neuralink Blindsight with The vOICe vision BCI (sensory substitution) through open collaboration with neuroscientists around the world https://www.artificialvision.com/literature.htm No NDAs, welcoming study reports on the good, the bad and the ugly; #translational #neuroscience

Let's beat Elon Musk's Neuralink Blindsight with The vOICe vision BCI (sensory substitution) through open collaboration with neuroscientists around the world https://www.artificialvision.com/literature.htm No NDAs, welcoming study reports on the good, the bad and the ugly; #translational #neuroscience

Newly awarded NIH grants for neuroscience lag 77 percent behind previous nine-year average https://www.thetransmitter.org/funding/newly-awarded-nih-grants-for-neuroscience-lag-77-percent-behind-previous-nine-year-average/ #NIH #neuroscience

I keep going back to this question about #TemporalCreditAssignment and #HippocampalReplay:
As an "agent" you want to learn the value of places and which places are likely to lead to reward;

-1) if a place leads to higher than expected reward, you'll want to propagate back the reward info from the reward throughout the places that led to the reward. If replay does that you should see an increase of replay at a new reward site and the replay sequences should start at the reward and reflect what you just did to reach it. Right?

-2) if a place leads to lower than expected reward, you'll also want to propagate that lowered value, pretty much in the same way, so if replay does that you should see a similar replay rate and content for increased OR decreased reward sites. Right?

-3) if a place has had unchanged reward for a while and you're just in exploitation mode (just going there again and again because you know that's the best place to go to in the environment) then you shouldn't need to update anything and replay rate should be quite low at that unchanged reward side. Right?

That's not at all what replay is doing IRL, so does that mean replay is not used for temporal credit assignment? Or did I (very likely) miss something?