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#aneuploidy

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Bianor Biotech SL

Hello, Fediverse! We are Bianor Biotech, a technology-based company that emerged from the University of León. The company was promoted by the Department of Molecular Biology (Cellular Biology) professors and INDEGSAL (fediscience.org/@indegsal), F. Martínez-Pastor and B. Martín-Fernández.
At Bianor Biotech, we specialize in reproductive biology, particularly sperm analysis. Our unique expertise lies in sperm chromatin analysis, which is crucial for clinics and companies in the livestock and animal breeding sector.
We are currently participating in the H2020 NeoGiANT project (neogiant.eu), which is researching ways to reduce the use of antibiotics in animal reproduction. We are excited to share our progress with you.
We are also on Bluesky, LinkedIn and bianorbiotech.es
#bianorbiotech #ReproSci #Science #ReproMed #Reproduction #ReproductionBiology #sperm #spermatology #spermatozoa #SpermChromatin #DNAfragmentation #SDF #DSB #aneuploidy #SpermAnalysis #NeoGiANT #H2020 #AMR

FediScience.orgINDEGSAL-ULe (@indegsal@fediscience.org)3 Posts, 30 Following, 4 Followers · Instituto de Sanidad Animal y Desarrollo Ganadero, Univ. de León. Investigación en sanidad, producción y reproducción animal. Servicios al sector ganadero, clínico e industrial. Docencia. Institute for Animal Health and Livestock Development, University of León, Spain. Research in animal health, production, and reproduction. Services to livestock breeders, industry, and veterinary clinical sector. OneHealth approach. Teaching. #AnimalHealth #OneHealth #AnimalProduction #Livestock #HigherEd
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Bianor Biotech SL

¡Un saludo al Fediverso! Esta es la cuenta de Bianor Biotech, una empresa de base tecnológica surgida de la Universidad de León, promovida por los profesores del Dpto. de Biología Molecular (Biología Celular) e INDEGSAL (fediscience.org/@indegsal) F. Martínez-Pastor y B. Martín-Fernández.
Trabajamos en biología de la reproducción y somos expertas en análisis espermáticos, especialmente análisis de la cromatina espermática para clínicas y empresas del sector ganadero y selección animal.
Actualmente, participamos en el proyecto H2020 NeoGiANT (neogiant.eu) investigando para reducir el uso de antibióticos en reproducción animal.
También estamos en Bluesky, LinkedIn y en bianorbiotech.es
#bianorbiotech #ReproSci #Science #ReproMed #Reproduction #BiologíaDeLaReproducción #sperm #spermatology #espermatozoide #SpermChromatin #DNAfragmentation #SDF #DSB #aneuploidy #SpermAnalysis #NeoGiANT #H2020 #AMR

FediScience.orgINDEGSAL-ULe (@indegsal@fediscience.org)3 Posts, 30 Following, 4 Followers · Instituto de Sanidad Animal y Desarrollo Ganadero, Univ. de León. Investigación en sanidad, producción y reproducción animal. Servicios al sector ganadero, clínico e industrial. Docencia. Institute for Animal Health and Livestock Development, University of León, Spain. Research in animal health, production, and reproduction. Services to livestock breeders, industry, and veterinary clinical sector. OneHealth approach. Teaching. #AnimalHealth #OneHealth #AnimalProduction #Livestock #HigherEd
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preLights

Hypoxia regulates embryonic fitness in mosaic aneuploid embryos.

In his first preLight, Anchel De Jaime Soguero highlights work from Estefania Sanchez-Vasquez, Marianne E. Bronner & Magdalena Zernicka-Goetz. #preprint

Read his preLight + responses from the authors below ⬇️ 👀

preLight 👉 prelights.biologists.com/highl

preLightsHIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos - preLightsHypoxia regulates embryonic fitness in mosaic aneuploid embryos
#biology#development#aneuploidy
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Charité Berlin

🔍 Puzzle solved 🎉: A #CharitéBerlin team has found out how cells deal with extra chromosomes.

The previously unknown mechanism could help identify lines of attack in dealing with treatment-resistant #tumors & fungal #infections. The fundamental findings have now been published in #Nature.

👉 charite.de/en/service/press_re

DNA of a healthy human cell with 26 chromosomes in all: 26 black chromosomes on a light background with four arms connected at one point. The 26 chromosomes vary in size and are scattered across the picture. Extra chromosomes normally cause a harmful genetic imbalance © CDC | Suzanne Trusler, MPH, DrPH
#CharitéPaper#CharitéBiomedicine#science
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John Urbanik

Enjoying this paper from the Sheltzer lab - it reads a bit like a group of biologists playing detective. They start with a theory that is necessary for the malignancy of some cancer lines, and then trace this all the way to showing some very tight links to MDM4. They even propose a therapeutic using differential sensitivity between disomic and trisomic cells.

biorxiv.org/content/10.1101/20

bioRxivOncogene-like addiction to aneuploidy in human cancersMost cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, we created a panel of isogenic cells that have or lack common aneuploidies, and we demonstrate that trisomy of chromosome 1q is required for malignant growth in cancers harboring this alteration. Mechanistically, gaining chromosome 1q increases the expression of MDM4 and suppresses TP53 signaling, and we show that TP53 mutations are mutually-exclusive with 1q aneuploidy in human cancers. Thus, specific aneuploidies play essential roles in tumorigenesis, raising the possibility that targeting these "aneuploidy addictions" could represent a novel approach for cancer treatment. ### Competing Interest Statement J.C.S. is a co-founder of Meliora Therapeutics, a member of the advisory board of Surface Ventures, and an employee of Google, Inc. This work was performed outside of her affiliation with Google and used no proprietary knowledge or materials from Google. J.M.S. has received consulting fees from Merck, Pfizer, Ono Pharmaceuticals, and Highside Capital Management, is a member of the advisory board of Tyra Biosciences and the Chemical Probes Portal, and is a co-founder of Meliora Therapeutics.
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