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#proteins

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Enabla

What determines the folding and stability of protein structures? In his fourth lecture, Dr. Ali Hassanali from the Abdus Salam International Centre for Theoretical Physics (ICTP) explores the intricate world of protein secondary structures, focusing specifically on alpha helices and beta sheets. Dr. Hassanali explains how these structures are stabilized through a variety of interactions, including hydrogen bonding and electrostatic effects, and the critical role of dihedral angles as illustrated by the Ramachandran plot.

This lecture also highlights the essential contributions of cysteine in forming disulfide bonds, which enhance protein stability in challenging environments. By examining the interplay of molecular interactions, Dr. Hassanali provides insights into the architectural and functional significance of these secondary structures as well as their evolutionary adaptations.

🎥 Join us for this #OpenAccess lecture and engage in discussions with Dr. Hassanali himself and other members of the Enabla community: enabla.com/pub/606/about

The ICTP diploma program lecture "Molecular Architecture and Stability of Protein Secondary Structures: Alpha Helices to Beta Sheets" by Dr. Ali Hassanali is on Enabla in Open Access! Video, English, 1.4 hours
#Biophysics#Proteins#MolecularBiology
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Science Updates

“I think it will be a gamechanger very broadly, not just for people in my field,” said senior study author James Liu, a group leader at Howard Hughes Medical Institute's Janelia Research Campus. “It was a tool developed to answer a very obscure question, but I think all biologists can use the technique in their favorite samples.”

#research #science #biotechnology #technology #RNA #proteins

labroots.com/trending/clinical

LabrootsCutting-Edge Tech Can ID RNA & Protein in Deep Tissues | Clinical And Molecular DxGenes have to be expressed in the right place, at the time, and at the right levels. Scientists wanted to know more about how the structure of DNA in cells | Clinical And Molecular Dx
Public
The Conversation U.S.

"Pac-Man with a ponytail" #proteins, as #GRK proteins are nicknamed, regulate everything from night vision to heartbeats. A structural biology scholar explains how studying their structure could enhance a range of drugs. theconversation.com/pac-man-wi
Priyanka Naik, Purdue University

The Conversation‘Pac-Man with a ponytail’ proteins regulate everything from night vision to heartbeats – studying what GRKs look like could improve an array of drugsMaster switches of cell communication, G protein-coupled receptor kinases are the target of many drugs across a range of diseases.
Public
michael

6-Mar-2025
A new algorithm sheds light on ‘disordered’ #proteins

The #IntrinsicallyDisorderedProteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making #structurePrediction particularly challenging. These proteins although exhibit chaotic and ‘disordered’ structures, they still perform essential functions.
eurekalert.org/news-releases/1 #science

EurekAlert!A new algorithm sheds light on ‘disordered’ proteinsResearchers from the Biomedical Sciences Research Center “Alexander Fleming” and the Centre for Misfolding Diseases at the University of Cambridge have found a way to predict the structure of a significant fraction of the proteome that was previously considered “dark” and difficult to be studied
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