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#effectiveness

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A quotation from Fletcher Knebel

But a democracy is different. Each of us has got to feel that we can influence events, no matter how slight the influence. When people start believing they can’t they get frustrated, and angry. They feel helpless and they start going to extremes.

Fletcher Knebel (1911-1993) American author
Seven Days in May, “Tuesday Afternoon” [Lyman] (1962)[with Charles W. Bailey II]

Sourcing, notes: wist.info/knebel-fletcher/7689…

WIST Quotations · Seven Days in May, "Tuesday Afternoon" [Lyman] (1962)[with Charles W. Bailey II] - Knebel, Fletcher | WIST QuotationsBut a democracy is different. Each of us has got to feel that we can influence events, no matter how slight the influence. When people start believing they can’t they get frustrated, and angry. They feel helpless and they start going to extremes.

A quotation from Teddy Roosevelt

   All men in whose character there is not an element of hardened baseness must admit the need in our public life of those qualities which we somewhat vaguely group together when we speak of “reform,” and all men of sound mind must also admit the need of efficiency.
   There are, of course, men of such low moral type, or of such ingrained cynicism, that they do not believe in the possibility of making anything better, or do not care to see things better. There are also men who are slightly disordered mentally, or who are cursed with a moral twist which makes them champion reforms less from a desire to do good to others than as a kind of tribute to their own righteousness, for the sake of emphasizing their own superiority. From neither of these classes can we get any real help in the unending struggle for righteousness.
   There remains the great body of the people, including the entire body of those through whom the salvation of the people must ultimately be worked out. All these men combine or seek to combine in varying degrees the quality of striving after the ideal, that is, the quality which makes men reformers, and the quality of so striving through practical methods — the quality which makes men efficient. Both qualities are absolutely essential. The absence of either makes the presence of the other worthless or worse.

Theodore Roosevelt (1858-1919) American politician, statesman, conservationist, writer, US President (1901-1909)
Essay (1900-06), “Latitude and Longitude Among Reformers,” The Century Magazine, Vol. 60, No. 2

Sourcing, notes: wist.info/roosevelt-theodore/1…

Much of the #effectiveness in software dev comes from working backwards. Start at the outcome.

e.g.,

* working backwards from the deployment environment to the developers' machines

* working backwards from test assertions to test set-ups

* working backwards from user outcomes to user journeys

#Hypnosis - as an example of a practical application of the paradigm of "#embodiment" and "#embededdness"

Abstract

The following essay will examine hypnosis as an example of a #practical #application of the #paradigm of "embodiment" and "embededdness" in more detail. In this context, an attempt will be made to prove the #effectiveness of the #hypnosis procedure with the help of #empirical #findings from #cognitive #neuroscience.

More at: philosophies.de/index.php/2022

#Effectiveness of #Pasteurization for #Inactivation of #H5N1 #Influenza Virus in Raw Whole #Milk, MedRxIV: medrxiv.org/content/10.1101/20

Complete inactivation was achieved after incubation of H5N1 spiked raw milk at 63C for 30 min. Complete viral inactivation was observed in 7 out of 8 replicates of raw milk samples treated at 72C for 15 sec. In 1 replicate, a 4.56 log reduction was achieved, which is about 1 log higher than average viral quantities detected in bulk tanks in affected areas.

medRxiv · Effectiveness of Pasteurization for the Inactivation of H5N1 Influenza Virus in Raw Whole MilkHighly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5Nx viruses continue to cause episodic incursions and have been detected in more than 12 taxonomic orders encompassing more than 80 avian species, land and marine mammals, including recent detections in dairy cattle. The HPAI H5N1 spillover to these important livestock species creates a new interface for human exposure and raises food safety concerns. Presence of H5N1 genetic material in one out of five retail pasteurized milk samples in the USA has prompted the evaluation of pasteurization processes for the inactivation of influenza viruses. Our study examined whether pasteurization could effectively inactivate HPAI H5N1 inoculated raw whole milk samples. We heated 1 mL of non-homogenized milk samples to attain an internal temperature of 63C or 72C and spiked with 6.3 log EID50 of clade 2.3.4.4b H5N1 virus. Complete inactivation was achieved after incubation of the H5N1 spiked raw milk at 63C for 30 minutes. In addition, complete viral inactivation was observed in seven out of eight replicates of raw milk samples treated at 72C for 15 seconds. In one replicate, a 4.56 log reduction was achieved, which is about 1 log higher than the average viral quantities detected in bulk tanks in affected areas. Therefore, we conclude that pasteurization of milk is an effective strategy for mitigation of risk of human exposure to milk contaminated with H5N1 virus. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement Canadian Food Inspection Agency Health Canada ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors
Continued thread

🌱 And what is the alternative, you may ask. The alternative is to respect our nature and understand that we are open systems. The organizational structure should match, which means that the organizational design should involve the people who are part of the organization! In that way, the operating model will focus on #effectiveness, which respects our nature and leverages what we are best at finding creative solutions for challenges. Together. As a group.

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