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#longevity

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Futurist Jim Carroll

**Megatrend #11** —"The future is not just extending lifespan, but our healthspan, by treating aging itself." - Futurist Jim Carroll

(Futurist Jim Carroll is writing a series on 30 Megatrends, which he first outlined in his book Dancing in the Rain: How Bold Leaders Grow Stronger in Stormy Times. The trends were shared in the book as a way of demonstrating that, despite any period of economic volatility, there is always long-term opportunity to be found. The book is now in print - learn more at dancing.jimcarroll.com)

Nobody wants to get old. Everybody will. The age-old dilemma, if you pardon the pun.

But lifespan extension through regenerative medicine, genetic therapies, and anti-aging technologies is creating new markets and challenging our assumptions about career timelines, retirement, and generational planning. The dawn of a new era in the science of longevity is upon us, offering a comprehensive overview of the rapidly advancing field dedicated to understanding and extending human life.

Read the full PDF report for more details.

pdf.jimcarroll.com/Megatrend11

There's a lot of detail that follows, but it's worthwhile to dig into this in the context of megatrend thinking. Coming together all at once is a lot of science, technology (AI), venture capital money, big, bold thinking, and creative R&D passion. In that context, the focus of this science has fundamentally shifted from merely extending lifespan to enhancing **healthspan** — the period of life spent in good health, free from chronic disease and disability.

This paradigm shift recognizes that adding years to life has little value without maintaining quality of life and functional independence.

Of course, with all this science and technology comes an age-old debate. (Pardon the pun again.) The fixed ceiling perspective argues that human biology has a programmed limit, with data suggesting a plateau around 115-125 years - i.e. we will never get older than that. In contrast, the negligible senescence theory points to species like the Greenland shark or the immortal jellyfish, which show no age-related decline. This suggests that aging is a technical problem that can ultimately be solved.

Overall, this is a very significant megatrend to watch, given how quickly it is moving but also given how our fascination with it will never age. (Sorry)

#Longevity #Healthspan #Aging #Regenerative #Science #Biotechnology #Genetics #Innovation #Medicine #Future

Original post: jimcarroll.com/2025/07/decodin

The vOICe vision BCI 🧠🇪🇺

Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participants medrxiv.org/content/10.1101/20 Utah array, #BCI #NeuroTech #longevity #lifetime

medRxiv · Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participantsBrain–computer interfaces have enabled people with paralysis to control computer cursors, operate prosthetic limbs, and communicate through handwriting, speech, and typing. Most high-performance demonstrations have used silicon microelectrode "Utah" arrays to record brain activity at single neuron resolution. However, reports so far have typically been limited to one or two individuals, with no systematic assessment of the longevity, decoding accuracy, and day–to–day stability properties of chronically implanted Utah arrays. Here, we present a comprehensive evaluation of 20 years of neural data from the BrainGate and BrainGate2 pilot clinical trials. This dataset spans 2,319 recording sessions and 20 arrays from the first 14 participants in these trials. On average, arrays successfully recorded neural spiking waveforms on 35.6% of electrodes, with only a 7% decline over the study enrollment period (up to 7.6 years, with a mean of 2.8 years). We assessed movement intention decoding performance using a "decoding signal-to-noise ratio" (dSNR) metric, and found that 11 of 14 arrays provided meaningful movement decoding throughout study enrollment (dSNR > 1). Three arrays reached a peak dSNR greater than 4.5, approaching that achieved during able-bodied computer mouse control (6.29). We also found that dSNR increases logarithmically with the number of electrodes, providing a pathway for scaling performance. Longevity and reliability of Utah array recordings in this study were better than in prior nonhuman primate studies. However, achieving peak performance consistently will require addressing unknown sources of variability. ### Competing Interest Statement The MGH Translational Research Center has a clinical research support agreement (CRSA) with Ability Neurotech, Axoft, Neuralink, Neurobionics, Paradromics, Reach Neuro, Precision Neuro, and Synchron, for which LRH provides consultative input. LRH is a non-compensated member of the Board of Directors of a nonprofit assistive communication device technology foundation (Speak Your Mind Foundation). Mass General Brigham (MGB) is convening the Implantable Brain-Computer Interface Collaborative Community (iBCI-CC); charitable gift agreements to MGB, including those received to date from Paradromics, Synchron, Precision Neuro, Neuralink, and Blackrock Neurotech, support the iBCI-CC, for which LRH provides effort. FRW is an inventor on intellectual property licensed by Stanford University to Blackrock Neurotech and Neuralink Corp. JPD is a Director and shareholder in Pathmaker Neurosystems and a shareholder in Beacon Biosignals. All other authors have no competing interests. ### Clinical Trial NCT00912041 ### Funding Statement This work was supported by Office of Research and Development, Department of Veterans Affairs (N2864C, N9228C, A4820R, A2295R, B6453R, B6459L, A6779L, P1155R, A2827R,A3803R), NIH NIDCD (R01DC009899), NIH NIDCD (U01DC017844), NIH NIDCD(R01DC014034), NIH NIDCD (U01DC019430), NIH NICHD-NCMRR (N01HD53403), NIH NICHD-NCMRR (N01HD10018), NIH NICHD-NCMRR (R01HD077220), NIH NINDS,(U01NS098968), NIH NINDS (U01NS062092), NIH NINDS (UH2NS095548), NIH NINDS(U01NS123101), NIH NICHD (RC1HD063931), Simons Foundation (543,045), Howard Hughes Medical Institute, Doris Duke Charitable Foundation, Conquer Paralysis Now (004698), AHA (19CSLOI34780000), ALS Association (20-MALS-553), Larry and Pamela Garlick, Samuel and Betsy Reeves, MGH-Deane Institute, The Executive Committee on Research (ECOR) of Massachusetts General Hospital, Wu Tsai Neurosciences Institute, Bio-X Institute at Stanford, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University School of Engineering, Brown University Office of the Vice President for Research ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The IRB of Stanford University, IRB of Mass General Brigham, IRB of Case Western Reserve University and the IRB of Providence VA Healthcare gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data required to reproduce these results will be publicly released upon acceptance in a peer-reviewed journal.
Lazarou Monkey Terror 🚀💙🌈

You and I all deserve a few extra decades for all the shit Capitalism has put us through as it dies.

"But bad people will have longevity as well!" then do something about the bad people rather than wait for them to die. ffs...

sciencealert.com/scientists-co

ScienceAlert · Scientists Confirm Anti-Aging Drug Appears to Prolong Life in AnimalsFor centuries, humans have searched for ways to extend life.
#Longevity#AntiAging
Headlines Africa

Africa: Older Men and Women Living Longer: [IPS] Portland, Usa -- Older men and women are now living longer than ever before. Across the globe, individuals who reach old age can expect to have more years of life ahead of them than in previous generations. However, these additional years of life, coupled with the disparities among and within countries, including variations between older men… newsfeed.facilit8.network/TLHP #AgingPopulation #Longevity #OlderAdults #SocialChallenges #EconomicDisparities

Cykonot

Is aging and senescence unique to multicellular organisms? Does the pressure to divide / mutate and respond to a changing environment require that established members of a population age-out, lest they evolutionarily stagnate & disappear?

The Systems Biology of Single-Cell Aging:
pmc.ncbi.nlm.nih.gov/articles/

Senescence in bacteria and its underlying mechanisms:
pmc.ncbi.nlm.nih.gov/articles/

PubMed Central (PMC)The Systems Biology of Single-Cell AgingAging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its effects are hampered by an incomplete understanding of its multi-faceted origins. Systems biology, the use of quantitative and computational methods to ...
#aging#longevity#science
Andrew Steele

New 30% mouse lifespan extension paper just dropped!

Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.

Read more here: andrewsteele.co.uk/blog/2025/0

Andrew Steele · New drug cocktail makes mice live 30% longer – Andrew SteeleRapamycin + anti-cancer drug trametinib does better than rapa on its own!
#aging#longevity#agingbiology
Peter Spork

Revolutionärer Barcode für Blutzellen

Forschenden aus Spanien und Deutschland gelang jetzt ein großer Durchbruch. Mit "EPI-Clone" können sie das epigenetisch aktive Muster der DNA-Methylierung tausender Blutzellen aus einer Probe so geschickt analysieren, dass jede Zelle individuell erfasst wird.

Diese Einzelzell-Epigenomik liefert regelrechte Barcodes der Zelle. Erste Erkenntnis: Im Alter ändert sich das Blutsystem deutlich. Immer weniger Stammzell-Linien müssen das gesamte Blutsystem erneuern. Das Risiko für chronische Entzündungen und damit Alterskrankheiten steigt.

Die Methode soll jetzt den Weg zu einer hochpräzisen Altersmedizin begleiten und den Erfolg zukünftiger #Longevity Medizin messbar machen.

Die Nature-Studie ist erst seit wenigen Stunden online. Ich berichte schon jetzt auf newsletter-epigenetik.de und am Freitag in der nächsten Ausgabe der #SporksScienceNews.
@riffreporter

Foto: Blutstammzellen der Maus in 20-facher Vergrößerung. (Bildrechte: Julia Rühle/Centro de Regulación Genómica)

Peter Spork

Epigenetik wird gerade zum Hype. Verantwortlich dafür ist das große Interesse an #Longevity, denn das Altern scheint ein epigenetisch gesteuertes Programm zu sein - und die #Epigenetik könnte uns helfen, den Alterungsprozess zu bremsen oder gar zurückzudrehen.

Doch Vorsicht: Ganz so einfach ist es nicht. Epigenetik ist weder Anti-Genetik noch eine Macht, die die #Genetik beherrscht oder sie gar kontrolliert. Genetisches Erbe, die gegenwärtige Umwelt und der Lebensstil sowie prägende, epigenetisch gespeicherte Erfahrungen aus der Vergangenheit wirken immer gemeinsam. Wir können sie NIE isoliert betrachten.

Es ist halt kompliziert: Mit der Veränderung epigenetischer Strukturen kann man keine Gene verändern. Man kann damit auch nicht vermeintlich "böse" Eigenschaften einfach so - ganz easy - ab- und vermeintlich "gute" Eigenschaften wieder anschalten. ...

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