Enjoying this paper from the Sheltzer lab - it reads a bit like a group of biologists playing detective. They start with a theory that #aneuploidy is necessary for the malignancy of some cancer lines, and then trace this all the way to showing some very tight links to MDM4. They even propose a therapeutic using differential sensitivity between disomic and trisomic cells.
The methods are fun too - some very clever use of CRISPR to truncate single copies of particular chromosome arms.