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#AlphaFold

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After #AlphaFold 1, the team tried to work without evolutionary information, to learn what they could do from physics. Accuracy was terrible (John Jumper’s words), but they learned a lot by changing the approach. Use the plausible but false structures to create a space of possibilities to explore iteratively. “Kind of surprisingly, it started to work.” #ismbeccb2025

😮 Charité study analyzes 400 million years of enzyme evolution!

With the aid of #AlphaFold AI, a research team has decoded the laws according to which #enzymes - which catalyze chemical reactions in all living things - evolve. The results, which have now been published in the scientific journal #Nature, are relevant to the development of new antibiotics, for example.

👉 charite.de/en/service/press_re

😮 Charité-Studie analysiert 400 Millionen Jahre Enzym-Evolution!

Mithilfe der #AlphaFold-KI hat ein Forschungsteam die Gesetzmäßigkeiten entschlüsselt, nach denen sich #Enzyme – die chemische Reaktionen in allen Lebewesen beschleunigen – weiterentwickeln. Die jetzt im Fachmagazin #Nature veröffentlichten Ergebnisse sind beispielsweise für die Entwicklung neuer Antibiotika relevant.

👉 charite.de/service/pressemitte

🧬 New review out in Drug Discovery Today:

🔗 doi.org/10.1016/j.drudis.2025.

We take a critical look at how AI — especially AlphaFold(-Multimer/3) — has changed protein complex prediction.

End-to-end models work well for rigid complexes. Flexibility, disorder, and transient interfaces remain unsolved.

AI is shiny. Biology is complicated. We map what’s working, what isn’t, and what’s next.

💥 Революция в биохимии! ИИ научился предсказывать и даже создавать белки 🧬. AlphaFold и Rosetta меняют всё: от медицины до экологии. Это начало новой эры в науке! 🔬🤖 #AlphaFold #ИИ #биохимия #наука #технологии #NobelPrize #AI #биотех #proteinfolding #DeepMind

Подробнее: scientia-et-innovatio.blogspot

🤖 AI | ⚛️ QUANTUM
🔴 Google Bets Big on Quantum-AI Synergy

🔸 New chip “Willow” achieves breakthrough error reduction via more qubits.
🔸 May generate novel training data as AI hits internet data limits.
🔸 Could power models like AlphaFold with quantum-informed insights.
🔸 Google targets real-world quantum use case in 5 years.

youtube.com/watch?v=P_fHJIYENd

Veritasium just released a great video of #ProteinFolding algorithms and #AlphaFold as part of the story.

The Veritasium team releases some of the best science videos around: accessible, clear and accurate. It's a great service to communicate this breakthrough to everyone.

#ScientificComputing #Bioinformatics #AI #MachineLearning #ScienceCommunication #ProteinDesign

P.S. shame about the anthropomorphic hype at the end