NEW from me @STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.

NEW from me @STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
What is the key idea of #AlphaFold? There isn't one. #ismbeccb2025
After #AlphaFold 1, the team tried to work without evolutionary information, to learn what they could do from physics. Accuracy was terrible (John Jumper’s words), but they learned a lot by changing the approach. Use the plausible but false structures to create a space of possibilities to explore iteratively. “Kind of surprisingly, it started to work.” #ismbeccb2025
First keynote of #ismbeccb2025: John Jumper, first but not last surely with #MachineLearning #AI at the center.
We all know about #AlphaFold, John will tell us about the challenges along the way. Good start! “Evolution is important”
AI for science, drug discovery to have ‘greatest impact’, says Nvidia’s Huang https://www.byteseu.com/1204271/ #AI #AIForScience #Alibaba #AlibabaCloud #AlphaFold #Beijing #biology #ByteDance #China #ChinaInternationalSupplyChainExpo #DamoAcademy #DrugDiscovery #JensenHuang #Science #WangJian
CASP, the protein structure competition that rocketed AlphaFold to fame and a Nobel, is losing its NIH funding.
David Baker on how CASP impacted his career (and Nobel Prize), and what's the latest on CASP's funding status:
Interesting post on the important limitations of #AlphaFold in helping us to truly understand protein structure and function.
Sorry, the post is on substack.
https://clauswilke.substack.com/p/no-alphafold-has-not-completely-solved
https://www.europesays.com/uk/254836/ The Unlikely Reasonableness of AI-Augmented HPC #AI #AlphaFold #Biology #Chemistry #Computing #LLMs #LQMs #OpenFold #Physics #Technology #UK #UnitedKingdom #Weather
https://www.europesays.com/2233124/ Hong Kong start-up IntelliGen AI aims to challenge Google DeepMind in drug discovery #Accenture #AI #AlphaFold #ArtificialIntelligence #Baidu #ByteDance #China #DeepMind #DrugDiscovery #FudanUniversity #FutureCapital #google #HongKong #IntelliGenAI #IsomorphicLabs #RonaldSun
Charité study analyzes 400 million years of enzyme evolution!
With the aid of #AlphaFold AI, a research team has decoded the laws according to which #enzymes - which catalyze chemical reactions in all living things - evolve. The results, which have now been published in the scientific journal #Nature, are relevant to the development of new antibiotics, for example.
Charité-Studie analysiert 400 Millionen Jahre Enzym-Evolution!
Mithilfe der #AlphaFold-KI hat ein Forschungsteam die Gesetzmäßigkeiten entschlüsselt, nach denen sich #Enzyme – die chemische Reaktionen in allen Lebewesen beschleunigen – weiterentwickeln. Die jetzt im Fachmagazin #Nature veröffentlichten Ergebnisse sind beispielsweise für die Entwicklung neuer Antibiotika relevant.
New review out in Drug Discovery Today:
https://doi.org/10.1016/j.drudis.2025.104382
We take a critical look at how AI — especially AlphaFold(-Multimer/3) — has changed protein complex prediction.
End-to-end models work well for rigid complexes. Flexibility, disorder, and transient interfaces remain unsolved.
AI is shiny. Biology is complicated. We map what’s working, what isn’t, and what’s next.
#uniprot just hides the controls.. so you can't even try to full screen. but you can fortunately link out the #ebi #alphafold site where (ctd..)
The new #AlphaEvolve from #DeepMind promises a general-purpose #AI for science - from solving math puzzles to improving chip designs, maybe as revolutionary as #AlphaFold. But until an open-source version is vetted by researchers, skepticism remains the safest policy.
#Google #ScienceAI #ResearchSky
DeepMind unveils ‘spectacular’...
Революция в биохимии! ИИ научился предсказывать и даже создавать белки
. AlphaFold и Rosetta меняют всё: от медицины до экологии. Это начало новой эры в науке!
#AlphaFold #ИИ #биохимия #наука #технологии #NobelPrize #AI #биотех #proteinfolding #DeepMind
Подробнее: https://scientia-et-innovatio.blogspot.com/2025/05/blog-post.html
AI |
QUANTUM
Google Bets Big on Quantum-AI Synergy
New chip “Willow” achieves breakthrough error reduction via more qubits.
May generate novel training data as AI hits internet data limits.
Could power models like AlphaFold with quantum-informed insights.
Google targets real-world quantum use case in 5 years.
Sundar Pichai: Google Pixel con AI "universale" in arrivo
#AI #AlphaFold #DeepMind #Futuro #GeminiAI #Google #GoogleGemini #GooglePixel #Innovazione #IntelligenzaArtificiale #Notizie #Smartphone #SundarPichai #TechNews #Tecnologia
https://www.ceotech.it/sundar-pichai-google-pixel-con-ai-universale-in-arrivo/
What if all the world's biggest problems shared the same solution?
This video nicely summarizes the gigantic leap in protein folding research and its subsequent future potential.
https://www.youtube.com/watch?v=P_fHJIYENdI #AlphaFold #DeepMind #AI
https://youtube.com/watch?v=P_fHJIYENdI&si=ECF7pagdnAgEwT4Z
Veritasium just released a great video of #ProteinFolding algorithms and #AlphaFold as part of the story.
The Veritasium team releases some of the best science videos around: accessible, clear and accurate. It's a great service to communicate this breakthrough to everyone.
#ScientificComputing #Bioinformatics #AI #MachineLearning #ScienceCommunication #ProteinDesign
P.S. shame about the anthropomorphic hype at the end