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**Megatrend #12** - Personalized, Precision Medicine: "Tomorrow's cure lies not in a universal pill, but within our own genetic code." - Futurist Jim Carroll

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(Futurist Jim Carroll is writing a series on 30 Megatrends, which he first outlined in his book Dancing in the Rain: How Bold Leaders Grow Stronger in Stormy Times. The trends were shared in the book as a way of demonstrating that, despite any period of economic volatility, there is always long-term opportunity to be found. The book is now in print - learn more at dancing.jimcarroll.com)

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The one-size-fits-all era in medicine is ending. Treatments, nutrition, and wellness approaches tailored to individual genetic profiles are becoming the standard, not the exception. As with every post in this series, there's a PDF here that goes into more depth on this trend.

There's a little bit of duplication with some of the material covered in previous megatrends with this one, but it's important ot note that this trend is powerful enough on its own to deserve its own post.

What's it all about? We are combining what we might call 'next-generation genomic sequencing', AI, and CRISPR gene editing, to come up with a new health paradigm that involves 'fixing people before they are sick rather than after.' Why these 3 trends? The cost for genomic sequencing is collapsing, AI is accelerating the ability to do so, and gene editing allows us to correct the genetic causes of disease at the source.

Before going further, it's important to define the revolution by understanding two key terms.

The first is Personalized Medicine, which uses an individual's unique genomic, environmental, and lifestyle information to guide decisions for prevention, diagnosis, and treatment of disease. It's based on the idea that because no two individuals are the same, they should not receive the same healthcare.

The second term is Precision Medicine. While often used interchangeably, it more accurately describes the strategy of stratifying individuals into small populations based on shared characteristics. It focuses on identifying which healthcare and pharmaceutical approaches will be most effective for those small, specific groups of people, rather than creating unique treatments for each individual.

While its potential is immense, the transition to personalized medicine is not merely a technological upgrade but a disruptive force that challenges the foundational structures of healthcare delivery, research, and regulation.

Even so, over the long term, it's one of the biggest megatrend opportunities of our time.

**#Personalized** **#Medicine** **#Genomics** **#CRISPR** **#AI** **#Precision** **#Healthcare** **#Genetics** **#Innovation** **#Future**

Original post: jimcarroll.com/2025/07/decodin

Un sensore di DNA grande come una carta di credito costa 50 centesimi e rileva cancro e HIV in 5 minuti. I ricercatori del MIT hanno creato un dispositivo che funziona senza refrigerazione per 2 mesi e promette di portare la diagnosi di laboratorio direttamente a domicilio.

#futuroprossimo #medicina #tecnologia #diagnostica #dna #cancro #crispr #hiv

futuroprossimo.it/2025/07/crea

A heartening story about how CRISPR is being used to develop citrus trees resistant to huanglongbing (HLB, also known as citrus greening), carried by the the Asian citrus psyllid.

In 20 years, the disease reduced citrus production in Florida by more than 60%: infected trees can die in as few as 5 years.

If all goes well, in 2027 resistant trees may be planted in commercial orchards.

pbs.org/newshour/show/how-rese

PBS News · How researchers in Florida are using gene editing to protect the state’s orange grovesBy Colleen Krantz, Iowa PBS

Just mind bogglingly amazing - modern #GeneEditing therapies! Doesn't get more #PrecisionMedicine than this!

"First Personalized CRISPR Gene Editing Therapy Patient Baby KJ Discharged

Three hundred and seven days after he was first admitted to Children’s Hospital of Philadelphia (CHOP), the 10-month-old went home after being treated with a bespoke base editing approach"

#Science #CRISPR #genetics
insideprecisionmedicine.com/to

Inside Precision Medicine · First Personalized CRISPR Gene Editing Therapy Patient Baby KJ DischargedBy Jonathan D. Grinstein, PhD

A Gene Editing Strategy to Repair Huntington's Defects

"A lot more studies would be needed before we can know if disrupting these repeats with a base editor could be a viable therapeutic strategy to treat patients. But being able to illuminate the biological consequences of interrupted repeats is a really useful and important milestone," explained senior study author Dr David Liu.

#CRISPR #genetics #research #biology #biotechnology #science #Huntingtons

labroots.com/trending/genetics