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#pathology

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Dr David Mills

Cheap circular polarised microscopy using lenses from 3D glasses. CPL has an advantage over linear polarised light for this in that you get complete resolution of the orientation of the birefringent sample rather than getting a Maltese cross effect on some orientations.
#microscopy #pathology

A slice of bone between two cheap 3D glasses CPL lenses. The background of the bone is dark, but the bone itself shows up the structure of the underlying collagen orientation.
Public
DB 🌱💦

Meet Nancy, the French 'antisemitism victim' who since last fall has been 'living in fear' due to relentless antisemitic harassment…

Well she's just been caught red-handed spray-painting the hateful graffiti and sending the threats to herself.

Now Nancy faces over €30,000 in fines and possible prison time.

#Antisemitism#France#Paris
Public
SPQR

“If you start at age 55 and go forward until your 95th birthday, there are two options: You die before dementia, or you get to dementia before death,”... From age 55 to 75, he noted, the risk of developing dementia is only about 4 percent. That increases substantially over the next two decades, particularly after people’s 85th birthdays.
#dementia #healthcare #pathology #aging #BrainScience #neurobiology
washingtonpost.com/health/2025

The Washington Post · 1 million U.S. adults will develop dementia each year by 2060, study saysBy Carolyn Y. Johnson
Continued thread
Public
preLights

2️⃣ Adriani highlights a study that explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments. #preprint from the Yamashita Lab.

#preLight: prelights.biologists.com/highl

preLightsFactor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit - preLightsCould blood thinners be made safer? This study explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments
#biochemistry#medicine#coagulation
Public
SPQR

We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.
#science #aging #exercise #physiology #biology #pathology #muscles #training #health
journals.plos.org/plosone/arti

journals.plos.orgResistance Exercise Reverses Aging in Human Skeletal MuscleHuman aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.
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